Affinity and efficacy studies of buprenorphine analogues at opioid receptors
Buprenorphine is a widely used analgesic. Its in vivo properties are partial agonism at μ-receptors and antagonism at κ-receptors. For the investigation of the role of the tertiary alcohol function in the pharmacology of buprenorphine, a series of ring constrained analogues of buprenorphine, in whic...
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| Format: | Default Thesis |
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1996
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| Online Access: | https://hdl.handle.net/2134/32925 |
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