Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina

Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient-specific RPE cells with the Complement Factor H Y402H high-risk polymorp...

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Main Authors: Marzena Kurzawa-Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelyte, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al-Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric-Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, Majlinda Lako
Format: Default Article
Published: 2022
Subjects:
Biochemistry and cell biology
age-related macular degeneration
complement factor H
extracellular vesicles
human induced pluripotent stem cells
retinal pigment epithelium
photoreceptors
retina
Online Access:https://hdl.handle.net/2134/22147502.v1
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https://hdl.handle.net/2134/22147502.v1

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