Abstract 14866: Exercise Ventilatory Efficiency in the Community: Relations With Cardiometabolic Risk Factors and Fitness

IntroductionVentilatory efficiency (VE/VCO2) throughout exercise is inversely related to adverse outcomes in heart disease patients, but the optimal measurement and cross-sectional relations of VE/VCO2 in the community are unknown.HypothesisCompared with the VE/VCO2 slope throughout exercise or afte...

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Published in:Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A14866-A14866
Main Authors: Nayor, Matthew G, Xanthakis, Vanessa, Tanguay, Melissa, Blodgett, Jasmine B, Shah, Ravi V, Malhotra, Rajeev, Houstis, Nicholas E, Velagaleti, Raghava S, Moore, Stephanie, Larson, Martin G, Vasan, Ramachandran S, Lewis, Gregory D
Format: Article
Language:English
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Summary:IntroductionVentilatory efficiency (VE/VCO2) throughout exercise is inversely related to adverse outcomes in heart disease patients, but the optimal measurement and cross-sectional relations of VE/VCO2 in the community are unknown.HypothesisCompared with the VE/VCO2 slope throughout exercise or after the ventilatory anaerobic threshold (VAT), the VE/VCO2 slope from the start of exercise to the VAT is more closely related with fitness and CV risk factors in the community.MethodsWe performed maximum incremental ramp cardiopulmonary exercise tests with breath-by-breath gas exchange measures on 1974 Framingham Study participants (age 54±9 yrs, 53% women, respiratory exchange ratios >1.0). We measured VE/VCO2slope to the VAT (pre-VAT), VE/VCO2slope after the VAT (post-VAT), and VE/VCO2slope throughout exercise (overall). We analyzed ln(VE/VCO2 slope) due to skewness.ResultsPre-VAT VE/VCO2slope (mean 24.8±3.3) was more closely related to peak oxygen consumption (VO2; correlation coefficient [r]= -0.34, p
ISSN:0009-7322
1524-4539