Bleomycin-detectable iron in the plasma of premature and full-term neonates

The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babi...

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Bibliographic Details
Published in:	FEBS letters 1992-06, Vol.303 (2), p.210-212
Main Authors:	Evans, Patricia J., Evans, Robert, Kovar, Ilya Z., Holton, Andrew F., Halliwell, Barry
Format:	Article
Language:	eng
Subjects:	assays Biochemistry & Molecular Biology Biological and medical sciences Biophysics Bleomycin Cell Biology Delivery. Postpartum. Lactation Free radical Gynecology. Andrology. Obstetrics Humans Hydrogen-Ion Concentration Infant, Newborn - blood Infant, Premature - blood iron Iron - blood Iron metabolism Iron overload Life Sciences & Biomedicine man Maternal, fetal and perinatal monitoring Medical sciences Neonate neonates plasma Science & Technology Transferrin utilization
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Summary:	The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.
ISSN:	0014-5793 1873-3468 1873-3468