An O2 Self-Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy

Conventional oxygen‐dependent photodynamic therapy (PDT) has faced severe challenges because of the non‐specificity of most available photosensitizers (PSs) and the hypoxic nature of tumor tissues. Here, an O2 self‐sufficient cell‐like biomimetic nanoplatform (CAT‐PS‐ZIF@Mem) consisting of the cance...

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Bibliographic Details
Published in:Advanced functional materials 2016-11, Vol.26 (43), p.7847-7860
Main Authors: Cheng, Hong, Zhu, Jing-Yi, Li, Shi-Ying, Zeng, Jin-Yue, Lei, Qi, Chen, Ke-Wei, Zhang, Chi, Zhang, Xian-Zheng
Format: Article
Language:English
Subjects:
catalase
cell membranes
hypoxia
metal-organic frameworks
photodynamic therapy
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Summary:Conventional oxygen‐dependent photodynamic therapy (PDT) has faced severe challenges because of the non‐specificity of most available photosensitizers (PSs) and the hypoxic nature of tumor tissues. Here, an O2 self‐sufficient cell‐like biomimetic nanoplatform (CAT‐PS‐ZIF@Mem) consisting of the cancer cell membrane (Mem) and a cytoskeleton‐like porous zeolitic imidazolate framework (ZIF‐8) with the embedded catalase (CAT) protein molecules and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4, defined as PS) is developed. Because of the immunological response and homologous targeting abilities of the cancer cell membrane, CAT‐PS‐ZIF@Mem is selectively accumulated at the tumor site and taken up effectively by tumor cells after intravenous injection. After the intracellular H2O2 penetration into the framework, it is catalyzed by CAT to produce O2 at the hypoxic tumor site, facilitating the generation of toxic 1O2 for highly effective PDT in vivo under near‐infrared irradiation. By integrating the immune escape, cell homologous recognition, and O2 self‐sufficiency, this cell‐like biomimetic nanoplatform demonstrates highly specific and efficient PDT against hypoxic tumor cells with much reduced side‐effect on normal tissues. An O2 self‐sufficient cell‐like biomimetic nanoplatform based on zeolitic imidazolate framework (ZIF‐8) is developed for effective photodynamic therapy (PDT). In vitro and in vivo investigations confirm that this cell‐like PDT agent possesses immune escape, homologous targeting, and O2 self‐sufficient capabilities for highly specific PDT against hypoxic tumor cells.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201603212