INVIVO EVALUATION OF AN ELECTROENZYMATIC GLUCOSE SENSOR IMPLANTED IN SUBCUTANEOUS TISSUE

Cleanroom processing techniques have been used to mass-produce flexible, electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro characterization studies have shown the sensor's performance to be acceptable. Initial in vivo studies were conducted with the sen...

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Bibliographic Details
Published in:Biosensors & bioelectronics 1992-01, Vol.7 (10), p.709-714
Main Authors: JOHNSON, KW, MASTROTOTARO, JJ, HOWEY, DC, BRUNELLE, RL, BURDENBRADY, PL, BRYAN, NA, ANDREW, CC, ROWE, HM, ALLEN, DJ, NOFFKE, BW, MCMAHAN, WC, MORFF, RJ, LIPSON, D, NEVIN, RS
Format: Article
Language:English
Subjects:
Biophysics
Biotechnology & Applied Microbiology
Chemistry
Chemistry, Analytical
Electrochemistry
Life Sciences & Biomedicine
Nanoscience & Nanotechnology
Physical Sciences
Science & Technology
Science & Technology - Other Topics
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Summary:Cleanroom processing techniques have been used to mass-produce flexible, electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro characterization studies have shown the sensor's performance to be acceptable. Initial in vivo studies were conducted with the sensor implanted in the subcutaneous tissue of rabbits. Sensors implanted in the subcutaneous tissue of normal human subjects showed an excellent correlation between glucose concentrations measured by the sensor and capillary finger sticks measured with a commercial analyzer.
ISSN:0956-5663
DOI:10.1016/0956-5663(92)85053-D