EFFECTS OF KETANSERIN AND MIANSERIN ON DELAYED NEURONAL DEATH INDUCED BY CEREBRAL-ISCHEMIA IN MONGOLIAN GERBILS

We examined whether ketanserin and mianserin, drugs with 5-HT2 receptor antagonistic effects, would have protective effects in Mongolian gerbils on delayed neuronal death induced by cerebral ischemia. When training and test sessions in the passive avoidance task were carried out 6 and 7 days after 3...

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Bibliographic Details
Published in:PSYCHOPHARMACOLOGY 1992-11, Vol.109 (3), p.264-270
Main Authors: KARASAWA, Y, ARAKI, H, OTOMO, S
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Cardiovascular system
Cell Death - drug effects
Cell Death - physiology
Gerbillinae
Hippocampus - drug effects
Hippocampus - pathology
Hippocampus - physiology
Ketanserin - pharmacology
Life Sciences & Biomedicine
Male
Medical sciences
Mianserin - pharmacology
Miscellaneous
Neurons - drug effects
Neurons - physiology
Neurosciences
Neurosciences & Neurology
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Psychiatry
Science & Technology
Scopolamine - pharmacology
Time Factors
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Summary:We examined whether ketanserin and mianserin, drugs with 5-HT2 receptor antagonistic effects, would have protective effects in Mongolian gerbils on delayed neuronal death induced by cerebral ischemia. When training and test sessions in the passive avoidance task were carried out 6 and 7 days after 3 min of ischemia, passive avoidance impairment was apparent. Destruction and disappearance was apparent in the hippocampal CA1 neurons at 7 days after the induced ischemia. Administration of ketanserin (5-20 mg/kg) and mianserin (5-20 mg/kg) led to better passive avoidance and prevented the delayed neuronal death induced by the ischemia. These effects of ketanserin and mianserin were not inhibited by treatment with the cholinergic blocker scopolamine (5 mg/kg). Thus, ketanserin and mianserin have a protective effect on delayed neuronal death in gerbils and the effects of these drugs are not mediated by serotonergic and cholinergic systems.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02245872