SUBCLINICAL HYPERTHYROIDISM - PHYSICAL AND MENTAL STATE OF PATIENTS

We investigated whether subclinical hyperthyroidism [subnormal basal thyroid-stimulating hormone (TSH) level, attenuated TSH response to thyrotropin-releasing hormone (TRH) stimulation, peripheral thyroid hormones within normal range] is accompanied by physical and mental changes. Thirty-five subcli...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 1992-07, Vol.241 (6), p.357-364
Main Authors: SCHLOTE, B, NOWOTNY, B, SCHAAF, L, KLEINBOHL, D, SCHMIDT, R, TEUBER, J, PASCHKE, R, VARDARLI, KAUMEIER, S, USADEL, KH
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Attention - physiology
Clinical Neurology
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Female
Humans
Hyperthyroidism - blood
Hyperthyroidism - diagnosis
Hyperthyroidism - psychology
Life Sciences & Biomedicine
Male
Mental Recall - physiology
Mental Status Schedule
Middle Aged
Neurocognitive Disorders - blood
Neurocognitive Disorders - diagnosis
Neurocognitive Disorders - psychology
Neurosciences & Neurology
Psychiatry
Psychomotor Performance - physiology
Science & Technology
Thyroid Hormones - blood
Thyrotropin - blood
Thyrotropin-Releasing Hormone
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Summary:We investigated whether subclinical hyperthyroidism [subnormal basal thyroid-stimulating hormone (TSH) level, attenuated TSH response to thyrotropin-releasing hormone (TRH) stimulation, peripheral thyroid hormones within normal range] is accompanied by physical and mental changes. Thirty-five subclinically hyperthyroid patients (27 female, 8 male) were compared with 60 overtly hyperthyroid patients (51 female, 9 male) and with 28 euthyroid control patients (18 female, 10 male) with respect to physical symptoms, affective state, short-term memory, ability to concentrate and psychomotor performance. Patients with subclinical hyperthyroidism ranged between the other two groups. The major difference between controls and subclinically hyperthyroid patients was an increase in frequency of nervous symptoms and symptoms due to an increase of metabolic rate and thermal regulation changes. The major differences between subclinically hyperthyroid and overtly hyperthyroid patients were psychomotor impairment and symptoms of increased metabolic rate. Self-ratings of affective state tended to be similar in patients with subclinical and overt hyperthyroidism. The ability to concentrate and short-term memory were not impaired in any group. Symptoms in patients with subclinical hyperthyroidism probably result from central changes which lead to attenuated TSH responses to TRH, or from elevated but still normal thyroxine levels, which possibly enhance the effect of catecholamines.
ISSN:0940-1334
1433-8491
DOI:10.1007/BF02191961