QUANTAL BIOASSAY AND STROKE

Background: Experimental investigation of stroke, in particular the evaluation of therapeutic maneuvers, is difficult because even well-controlled experiments show considerable variability. Optimal use of resources requires efficient statistical analysis. Summary of Review: A body of experience in p...

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Bibliographic Details
Published in:Stroke (1970) 1992-05, Vol.23 (5), p.767-773
Main Authors: ZIVIN, JA, WAUD, DR
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Assay - methods
Cardiovascular System & Cardiology
Cerebrovascular Disorders - drug therapy
Clinical Neurology
Dose-Response Relationship, Drug
Humans
Life Sciences & Biomedicine
Medical sciences
Models, Biological
Neurology
Neurosciences & Neurology
Peripheral Vascular Disease
Science & Technology
Vascular diseases and vascular malformations of the nervous system
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Summary:Background: Experimental investigation of stroke, in particular the evaluation of therapeutic maneuvers, is difficult because even well-controlled experiments show considerable variability. Optimal use of resources requires efficient statistical analysis. Summary of Review: A body of experience in pharmacology that is directly applicable to stroke studies is reviewed. The general approach, though well known to pharmacologists, is less familiar to neurologists. This paper attempts to give a survey so that neurologists encountering studies using this general class of analysis will better be able to put the technique into context. The general nature of a quantal bioassay is described, the underlying conceptual models are discussed, and specific examples are given. Conclusions: The pharmacologist's approach to the analysis of quantal bioassays can easily be adapted to the quantification of results in studies of stroke.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.23.5.767