ISOLATION AND CHARACTERIZATION OF RESPIRATION-DEFICIENT MUTANTS FROM THE PATHOGENIC YEAST CANDIDA-ALBICANS

The isolation of several respiration deficient mutants of the pathogenic yeast Candida albicans is described. These show greatly reduced respiration rates, loss of cytochromes aa3 and b, and reduced growth rates. All of the mutants had lost the ability to assimilate a wide range of carbon sources. U...

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Bibliographic Details
Published in:Antonie van Leeuwenhoek 1992-04, Vol.61 (3), p.207-219
Main Authors: ABUHATAB, M, WHITTAKER, PA
Format: Article
Language:English
Subjects:
Antimycin A - analogs & derivatives
Antimycin A - toxicity
Biological and medical sciences
Candida albicans - genetics
Candida albicans - growth & development
Candida albicans - metabolism
Candida albicans - ultrastructure
Carbohydrate Metabolism
Classical genetics, quantitative genetics, hybrids
Cyanides - toxicity
Cytochrome b Group - analysis
Cytochrome c Group - analysis
Fermentation
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Life Sciences & Biomedicine
Microbiology
Microscopy, Electron
Mitochondria - ultrastructure
Mutation
Oxygen Consumption
Science & Technology
Spectrophotometry, Ultraviolet
Thallophyta, bryophyta
Vegetals
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Summary:The isolation of several respiration deficient mutants of the pathogenic yeast Candida albicans is described. These show greatly reduced respiration rates, loss of cytochromes aa3 and b, and reduced growth rates. All of the mutants had lost the ability to assimilate a wide range of carbon sources. Ultrastructural studies showed reduced development of mitochondrial cristae in the mutants. The mutants can be divided into three classes depending on their respiration responses to the addition of cyanide.
ISSN:0003-6072
1572-9699
DOI:10.1007/BF00584227