Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer

Background Sirtuin 1 （SIRT1） has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins.However,the correlations among SIRT1 protein expression,clinicopathological parameters,and survival of colorectal cancer patients remain uncle...

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Published in:Chinese medical journal 2014-06, Vol.127 (11), p.2021-2024
Main Authors: Jiang, Kewei, Lyu, Liang, Shen, Zhanlong, Zhang, Jizhun, Zhang, Hui, Dong, Jianqiang, Yan, Yichao, Liu, Fangfang, Wang, Shan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Male
Middle Aged
Prognosis
Retrospective Studies
Sirtuin 1 - metabolism
临床病理
晚期
生物过程
结直肠癌
脱乙酰化
调节蛋白
非组蛋白
预后
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Summary:Background Sirtuin 1 （SIRT1） has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins.However,the correlations among SIRT1 protein expression,clinicopathological parameters,and survival of colorectal cancer patients remain unclear.Methods SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray,including 120 paired colorectal cancer and normal mucosa tissues.The correlations among SIRT1 protein expression,clinicopathological features,and prognosis were analyzed.Results All samples （100%） were positive for SIRT1,with variable staining in the cytoplasm rather than in the nucleus.There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissue （P〈0.01,x2 test）.SIRT1 overexpression was more frequently observed in advanced-stage tumors （P=0.046,0.002,x2test）.SIRT1 overexpression was significantly correlated with poor overall survival （P=0.013,log-rank test） and diseasefree survival （P=0.012,log-rank test）.Conclusions SIRT1 overexpression correlated with advanced stage and poor prognosis.SIRT1 may play an important role in the progression of colorectal cancer.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20140044