A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma

Background It remains a challenge to inhibit the local recurrence or distant metastasis of localized or locally advanced renal cell carcinoma （RCC） after surgical resection. We investigated the feasibility, safety and efficacy of immunotherapy using autologous tumor lysate （TL）-pulsed dendritic cell...

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Bibliographic Details
Published in:Chinese medical journal 2012-11, Vol.125 (21), p.3771-3777
Main Authors: Zhan, Hai-Lun, Gao, Xin, Pu, Xiao-Yong, Li, Wei, Li, Zhi-Jian, Zhou, Xiang-Fu, Qiu, Jian-Guang
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Renal Cell - immunology
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - therapy
Cytokine-Induced Killer Cells - immunology
Dendritic Cells - immunology
Female
Humans
Immunotherapy
Kidney Neoplasms - immunology
Kidney Neoplasms - mortality
Kidney Neoplasms - therapy
Male
Middle Aged
T-Lymphocyte Subsets - immunology
免疫治疗
晚期
杀伤细胞
树突状细胞
细胞因子
细胞裂解
肾细胞
随机对照试验
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Summary:Background It remains a challenge to inhibit the local recurrence or distant metastasis of localized or locally advanced renal cell carcinoma （RCC） after surgical resection. We investigated the feasibility, safety and efficacy of immunotherapy using autologous tumor lysate （TL）-pulsed dendritic cells （DCs） and cytokine-induced killer （CIK） cells in patients with localized or locally advanced RCC.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.21.004