Evaluating the oncologic outcomes in 152 patients undergoing extraperitoneal laparoscopic radical prostatectomy

Background Although many midterm oncologic data have been reported for extraperitoneal laparoscopic radical prostatectomy （ELRP） in western countries, few oncologic data of the extraperitoneal procedure was published in China. The aim of the study was to evaluate the oncologic outcomes of patients t...

Full description

Saved in:
Bibliographic Details
Published in:Chinese medical journal 2012-05, Vol.125 (9), p.1529-1535
Main Authors: Li, Xun-Gang, Zhang, Dong-Xu, Cui, Xin-Gang, Xu, Dan-Feng, Hong, Yi, Li, Yao, Gao, Yi, Liu, Yu-Shan, Yin, Lei, Qu, Fa-Jun, Wang, Jun-Kai, Chen, Ming, Chen, Jie, Chen, Lu, Wang, Kai
Format: Article
Language:English
Subjects:
Aged
Humans
Laparoscopy - methods
Male
Middle Aged
Prostate - surgery
Prostatectomy - methods
Prostatic Neoplasms - surgery
Treatment Outcome
前列腺癌
患者
成果评价
肿瘤学
腹腔镜
腹膜
西方国家
诊断方法
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Although many midterm oncologic data have been reported for extraperitoneal laparoscopic radical prostatectomy （ELRP） in western countries, few oncologic data of the extraperitoneal procedure was published in China. The aim of the study was to evaluate the oncologic outcomes of patients treated with ELRP in China. Methods From January 2005 to March 2010, a total of 152 consecutive patients diagnosed with clinically localized prostate cancer were included in this study and treated with ELRP. The patients were staged according to the TNM （tumor, nodes, metastases） system. Median and mean postoperative follow-up were 28.1 months and 27.0 months, respectively. The patients were retrospectively analyzed for progression-free survival. Results One hundred and twelve cases （73.7%） were postoperatively diagnosed as pT2 in, and 40 cases （26.3%） as pT3. Positive lymph nodes were shown in 5 patients （3.3%）. Gleason score was 〈7 in 49 men （32.2%）, 7 in 69 men （45.4%）, and 〉7 in 34 men （22.4%）. Positive surgical margins （PSM） were observed in 15 patients （9.9%）, which included 32.0% of all pT3a cases and 46.7% of all pT3b cases, respectively. The overall prostate-specific antigen recurrence-free survival rate was 86% in all patients. The recurrence-free survival rates were 91.8% and 62.2% in pT2N0 patients and pT3N0 patients, respectively. Preoperative prostate-specific antigen, surgical margins, tumor stage, and lymph nodal status were identified as independent predictors of biochemical recurrence-free survival using multivariate Cox proportional hazard model. Conclusions ELRP is a precise, safe and effective procedure at this particular Chinese institution. The prognostic power of prostate-specific antigen relapse after ELRP is not identical to that described previously with transperitoneal or open retropubic approaches.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.09.002