Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice

Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,

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Bibliographic Details
Published in:Chinese medical journal 2011-04, Vol.124 (7), p.1075-1081
Main Authors: Wang, Jin-Song, Liu, Xia, Xue, Zhen-Yi, Alderman, Lee, Tilan, Justin U, Adenika, Remi, Epstein, Stephen E, Burnett, Mary Susan
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Blotting, Western
Chemokine CXCL12 - metabolism
Female
Hindlimb - metabolism
Hindlimb - pathology
Hindlimb - physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Ischemia - metabolism
Ischemia - physiopathology
Matrix Metalloproteinase 9 - metabolism
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Necrosis - metabolism
Necrosis - pathology
Necrosis - physiopathology
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - physiopathology
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-1 - genetics
Vascular Endothelial Growth Factor Receptor-1 - metabolism
基因表达
小鼠
急性
新生血管形成
时间
缺血
老化
肢体
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Description
Summary:Background Molecular analysis of neovascularization related genes by time course in response to ischemia has not been described in the context of aging. We aimed to provide a progressively deeper understanding of how aging compromises neovascularization,
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2011.07.023