Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

A novel meroterpenoid, named meroterpenthiazole A (1), was isolated from the deep-sea-derived Penicillium allii-sativi. Its structure was established by extensive spectroscopic and computational methods. Meroterpenthiazole A bears a rare benzothiazole moiety in nature. Compound 1 significantly inhib...

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Bibliographic Details
Published in:Chinese chemical letters 2022-04, Vol.33 (4), p.2057-2059
Main Authors: Xie, Chun-Lan, Zhang, Duo, Guo, Kai-Qiang, Yan, Qing-Xiang, Zou, Zheng-Biao, He, Zhi-Hui, Wu, Zhen, Zhang, Xiao-Kun, Chen, Hai-Feng, Yang, Xian-Wen
Format: Article
Language:English
Subjects:
Deep-sea
Fungus
Meroterpenoids
Penicillium allii-sativi
Retinoid X receptor
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Summary:A novel meroterpenoid, named meroterpenthiazole A (1), was isolated from the deep-sea-derived Penicillium allii-sativi. Its structure was established by extensive spectroscopic and computational methods. Meroterpenthiazole A bears a rare benzothiazole moiety in nature. Compound 1 significantly inhibited retinoid X receptor (RXR)-α transcriptional effect (KD = 12.3 µmol/L) through a novel binding mechanism. [Display omitted]
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2021.09.073