Dichloromethane as a methylene synthon for regioselective linkage of diverse carboxylic acids: Direct access to methylene diesters under metal-free conditions

This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality of this protocol. [Dis...

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Bibliographic Details
Published in:Chinese chemical letters 2019-06, Vol.30 (6), p.1173-1177
Main Authors: Wang, Shuiliang, Fu, Zhengjiang, Huang, Zhicong, Jiang, Yongqing, Guo, Shengmei, Cai, Hu
Format: Article
Language:English
Subjects:
Carboxylic acids
Dichloromethane
Metal-free conditions
Methylene diesters
Methylene synthon
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Summary:This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality of this protocol. [Display omitted] A metal-free cross coupling between common CH2Cl2 and carboxylic acids has been achieved with K2CO3 as the sole additive. This simple protocol is a convenient and cost-effective route to synthesize methylene diesters from a wide scope of carboxylic acids substrates with good functional group tolerance. Several gram-scale reactions have been performed to evaluate the effectiveness and practicality of this protocol.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2019.04.053