Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol amines.Compounds 6a,e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluor...

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Bibliographic Details
Published in:Chinese chemical letters 2013-05, Vol.24 (5), p.415-418
Main Authors: Lu, Ming-Dong, Zhou, Xiao, Yu, Yao-Jun, Li, Pi-Hong, Sun, Wei-Jian, Zhao, Cheng-Guang, Zheng, Zhi-Qiang, You, Tao, Wang, Fei-Hai
Format: Article
Language:English
Subjects:
Anti-tumor agents
Cytotoxic activities
Furoxans NO donor
Hydroxylcinnamic acids
Synthesis
体外
合成
抗肿瘤剂
氧化呋咱
氮释放
生物活性评价
肿瘤细胞
衍生物
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Summary:Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol amines.Compounds 6a,e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluorouracil（5-FU） in most cancer cells tested.Furthermore,6f could selectively inhibit tumor cells,but not non-tumor cell proliferation.This inhibition was attributed to high levels of NO released in cancer cells and potentially synergistic effect of NO donor moieties and the bioactivity of hydroxylcinnamic acids.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.03.006