Atropisomerism of diastereomer diribonucleoside phosphotriester

Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds, such as cyclic bis（3＇-5＇） diguanylic acid （c-di-GMP） and its analogues. Atropisomerism of diastereomers generated by the chiral center of the P atom, which results in the doubling...

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Bibliographic Details
Published in:Chinese chemical letters 2013, Vol.24 (1), p.13-16
Main Authors: Na, Lu-Xin, Sun, Xu-Lin, Wang, Meng, Li, Kun-Feng, Xing, Lei, Chen, Zhuo, Guan, Zhu, Yang, Zhen-Jun
Format: Article
Language:English
Subjects:
31P NMR
Atropisomer
Diribonucleoside phosphotriester
NMR信号
中间体
化合物
合成生物学
手性中心
磷酸三酯
类似物
非对映异构体
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Summary:Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds, such as cyclic bis（3＇-5＇） diguanylic acid （c-di-GMP） and its analogues. Atropisomerism of diastereomers generated by the chiral center of the P atom, which results in the doubling of signals in 31p NMR. The data of 31p NMR at different temperature are presented, and thereafter the reason is discussed.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.01.018