Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C

AIM： To confirm the predictive factors for interferon （IFN）-α and ribavirin combination therapy for chronic hepatitis patients with hepatitis C virus （HCV） genotype lb. METHODS： HCV RNA from 50 patients infected with HCV genotype lb was studied by cloning and sequencing of interferon sensitivity det...

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Published in:World journal of gastroenterology : WJG 2007-12, Vol.13 (46), p.6236-6242
Main Authors: Yoon, Joonho, Lee, Jong In, Baik, Soon Koo, Lee, Kwang Ho, Sohn, Joon Hyung, Lee, Hyean Woo, Namkung, Jun, Chang, Sei Jin, Choi, Jong Whan, Kim, Hyun Won, Yeh, Byung-Il
Format: Article
Language:English
Subjects:
Adult
Age Factors
Alanine Transaminase - blood
Amino Acid Sequence
Antiviral Agents - therapeutic use
Drug Therapy, Combination
Female
Hepacivirus - genetics
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - drug therapy
Humans
Interferon-alpha - therapeutic use
Liver - enzymology
Male
Middle Aged
Mutation
Predictive Value of Tests
Ribavirin - therapeutic use
RNA, Viral - blood
RNA, Viral - drug effects
RNA, Viral - genetics
Treatment Outcome
丙肝病毒
干扰素
病毒唑
磷酸化
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Summary:AIM： To confirm the predictive factors for interferon （IFN）-α and ribavirin combination therapy for chronic hepatitis patients with hepatitis C virus （HCV） genotype lb. METHODS： HCV RNA from 50 patients infected with HCV genotype lb was studied by cloning and sequencing of interferon sensitivity determining region （ISDR）, PKR- eIF2α phosphorylation homology domain （PePHD）. Patients were treated with IFN-α and ribavirin for 6 mo and grouped by effectiveness of the therapy. A variety of factors were analyzed. RESULTS： Our data showed that age, HCV RNA titer, and ISDR type could be used as the predictive factors for combined IFN-α and ribavirin efficacy. Characteristically, mutations in PePHD appeared only when the combination therapy was effective. Other factors, such as sex and alanine aminotransferase （ALT） level, were not related to its efficacy. Adjusting for age and HCV RNA titer indicated that the ISDR type was the most potent predictive factor. CONCLUSION： HCV RNA ISDR type is an important factor for predicting efficacy of IFN-α and ribavirin combination therapy in Korean patients.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.13.6236