HLA-A02-B46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma

Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In t...

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Published in:Journal of Huazhong University of Science and Technology. Medical sciences 2016-10, Vol.36 (5), p.700-704
Main Authors: Wang, Ruo-zheng, Zhang, Dian-gang, Wu, Ran, Hu, Yun-hui, Peng, Yan-chun, Chang, Cheng, Dong, Tao, Wang, Xi-yan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Carcinoma
Child
Disease-Free Survival
Female
Haplotypes
HLA-A Antigens - genetics
HLA-B Antigens - genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - pathology
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Retrospective Studies
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Summary:Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS ( P =0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC.
ISSN:1672-0733
1993-1352
DOI:10.1007/s11596-016-1647-y