Expression of prothymosin α predicts early recurrence and poor prognosis of hepatocellular carcinoma

BACKGROUND：Prothymosinα（PTMA）is a nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation.PTMA was overexpressed in several human malignancies including hepatocellular carcinoma（HCC）.However,the prognostic significance of PTMA protein expression in HCC remains...

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Published in:Hepatobiliary & pancreatic diseases international 2015-04, Vol.14 (2), p.171-177
Main Authors: Ha, Sang Yun, Song, Dae Hyun, Hwang, Soo Hyun, Cho, Soo Youn, Park, Cheol-Keun
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - metabolism
Carcinoma, Hepatocellular - chemistry
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - surgery
Disease-Free Survival
Endocrinology & Metabolism
Female
Follow-Up Studies
Gastroenterology and Hepatology
Hepatectomy
hepatocellular carcinoma
Humans
Liver Neoplasms - chemistry
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Recurrence, Local - chemistry
Neoplasm Staging
Predictive Value of Tests
Protein Precursors - analysis
prothymosin α
recurrence
Survival Rate
Thymosin - analogs & derivatives
Thymosin - analysis
Tumor Burden
复发
恶性肿瘤
早期
肝癌
胸腺素
蛋白表达
预后
预测性
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Summary:BACKGROUND：Prothymosinα（PTMA）is a nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation.PTMA was overexpressed in several human malignancies including hepatocellular carcinoma（HCC）.However,the prognostic significance of PTMA protein expression in HCC remains unclear.In the present study,we evaluated PTMA protein expression by immunohistochemistry in order to elucidate the prognostic roles of PTMA in HCC patients.METHODS： By immunohistochemistry, we investigated the expression of PTMA protein in tumor tissue from 226 HCC patients who underwent curative hepatectomy. Univariate and multivariate analyses were performed to evaluate its predic- tive value for tumor recurrence and survival of patients. The median follow-up period was 120 months. RESULTS： PTMA expression was observed in 162 （71.7%） of the 226 HCC patients and was significantly associated with higher Edmondson grade, microvascular invasion, intrahe- patic metastasis, higher American Joint Committee on Cancer （AJCC） T-stage, and lower albumin level. PTMA expression was an independent predictor of early recurrence （P=0.001）. PTMA expression showed an unfavorable influence on recurrence- free survival （RFS） （P〈0.001）. Subgroup analysis showed that among patients with tumor size _〈5.0 cm （140 patients）, patients at AJCC T-stage I （95 patients） and patients with a-fetoprotein ≤20 ng/mL （83 patients）, the differences in RFS between PTMA- positive and PTMA-negative groups were also statistically sig- nificant （P=0.017, P=0.002 and P=0.002, respectively）. In addi- tion, PTMA expression was an independent predictor of shorter RFS （P=0.011）. PTMA expression showed an unfavorable influ- ence on overall survival （P=0.014）, but was not an independent predictor of shorter overall survival （P=0.161）. CONCLUSIONS： PTMA protein expression might be a novel predictor of early recurrence and RFS in HCC patients, even those at early stage or with a-fetoprotein-negative after curative hepatectomy. PTMA could be used as an immunohistochemical biomarker to detect patients with a high risk of recurrence.
ISSN:1499-3872
DOI:10.1016/S1499-3872(14)60326-X