Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14+CD16+ Monocytes in a Population of Weifang, China

To investigate the relationship between human cytomegalovirus (HCMV) infection and peripheral blood CD14+CD16+ monocytes in the pathogenesis of coronary heart disease (CHD), and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection, inflammation, and CHD, t...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2020-08, Vol.33 (8), p.573-582
Main Authors: LI, Hong Zheng, WANG, Qin, ZHANG, Yi Yuan, WANG, Jin Dong, WU, Hong Juan, ZHANG, Mo Gen, LI, Ji Chen, LIU, Zhi Jun
Format: Article
Language:English
Subjects:
Angina Pectoris - epidemiology
Angina Pectoris - virology
Antibody
CD14+CD16+ monocytes
China - epidemiology
Coronary Disease - epidemiology
Coronary Disease - virology
Coronary heart disease
Cytomegalovirus - physiology
Cytomegalovirus Infections - complications
Human cytomegalovirus
Humans
Incidence
Inflammation - epidemiology
Inflammation - etiology
Leukocyte Count
Monocytes - metabolism
Myocardial Infarction - epidemiology
Myocardial Infarction - virology
Weifang
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Summary:To investigate the relationship between human cytomegalovirus (HCMV) infection and peripheral blood CD14+CD16+ monocytes in the pathogenesis of coronary heart disease (CHD), and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection, inflammation, and CHD, to provide a basis for the prevention, evaluation, and treatment of the disease. In total, 192 patients with CHD were divided into three groups: latent CHD, angina pectoris, and myocardial infarction. HCMV-IgM and -IgG antibodies were assessed using ELISA; CD14+CD16+ monocytes were counted using a five-type automated hematology analyzer; mononuclear cells were assessed using fluorescence-activated cell sorting; and an automatic biochemical analyzer was used to measure the levels of triglyceride, cholesterol, high- and low-density lipoprotein cholesterols, lipoprotein, hs-CRp and Hcy. The positive rates of HCMV-IgM and -IgG were significantly higher in the CHD groups than in the control group. HCMV infection affects lipid metabolism to promote immune and inflammatory responses. HCMV infection has a specific correlation with the occurrence and development of CHD. The expression of CD14+CD16+ mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection. Thus, HCMV antibody as well as peripheral blood CD14+CD16+ mononuclear cells can be used to monitor the occurrence and development of CHD.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2020.076