Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China

Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and...

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Published in:Biomedical and environmental sciences 2016-11, Vol.29 (11), p.790-801
Main Authors: YIN, Wen Jiao, SHEN, Li Ping, WANG, Fu Zhen, ZHANG, Guo Min, ZHENG, Hui, WANG, Feng, LIU, Tie Zhu, MENG, Qing Ling, YI, Yao, CUI, Fu Qiang, BI, Sheng Li
Format: Article
Language:English
Subjects:
Adult
Animals
China - epidemiology
CHO Cells
Cricetinae
Cricetulus
Female
Gene characteristics
Hepatitis B - congenital
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B - transmission
Hepatitis B Vaccines - therapeutic use
Hepatitis B virus - genetics
Humans
Immune escape
Infant, Newborn
Infectious Disease Transmission, Vertical
Mother-to-infant transmission
Mutation
Phylogeny
Pregnancy
Scheduled vaccination
Treatment Failure
Young Adult
‘a’ determinant mutation
中国地区
乙型肝炎病毒
乙肝
免疫预防
基因组测序
病毒基因
病毒感染
血清学检测
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Summary:Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2016.106