The Epidemiological Characteristics of Beijing Lineage Mycobacterium tuberculosis from a National Referral Center in China

Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains w...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2015-07, Vol.28 (7), p.539-543
Main Authors: LI, Xiao Ying, LI, Ying, ZHANG, Yao, KANG, Wan Li, ZHAO, Li Ping, DING, Peng Ju, DAI, Wen Tao, HUANG, Hai Rong, HUANG, Yan Feng, LI, Wei Min
Format: Article
Language:English
Subjects:
China - epidemiology
DNA, Bacterial - genetics
Genome, Bacterial
Hospitals, Chronic Disease
Humans
Molecular Epidemiology
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Phylogeny
Phylogeography
Polymorphism, Single Nucleotide
Tuberculosis - epidemiology
Tuberculosis - microbiology
中国
分化基因
北京
单核苷酸多态性
基因分型
多态性分析
流行病学特征
结核分枝杆菌
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Summary:Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, ＇modern＇ and ＇ancient＇ strains respectively represented 85.5% （324/379） and 14.5% （55/379）. Rv2494 （V48A） and Rv0245 （Sl03F） were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in ＇extreme＇ host condition.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2015.077