Influence of Soy Isoflavone on Lindane Cumulant in Sprague-Dawley Rats

Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2014-08, Vol.27 (8), p.637-640
Main Authors: Yang, Yang, Zhang, Yun Bo, Sheng, Wei, Fu, Zheng Hai, Wang, Zhe, Wang, Xiao, Guan, Si Yuan, Na, Xiao Lin
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Estradiol - blood
Female
Glycine max - chemistry
Hexachlorocyclohexane - pharmacology
Isoflavones - pharmacology
Rats
Rats, Sprague-Dawley
SD大鼠
Testosterone - blood
Uterus - drug effects
大豆异黄酮
子宫
林丹
清水
累积量
雌二醇
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Summary:Female Sprague-Dawley rats weighing 60-80 t were given different dosages of soy isoflavone! and/or lindane for four weeks. Soy isoflavones wa! added in feed and lindane was given by oral gavag（ We found that soy isoflavones could reduce the level of lindane in rat＇s serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat＇s body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat＇s uterus.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2014.097