Toxic Effects of Atrazine on Reproductive System of Male Rats

Objective This study was designed to evaluate the toxic effects of Atrazine （ATZ） on the reproductive system of male rats. 〈br〉 Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed thro...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2014-04, Vol.27 (4), p.281-288
Main Authors: SONG, Yang, JIA, Zhen Chao, CHEN, Jin Yao, HU, Jun Xiang, ZHANG, Li Shi
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Atrazine
Atrazine - toxicity
Body Weight - drug effects
Endocrine disrupter
Herbicides - toxicity
Hormones - blood
Male
Organ Size - drug effects
Oxidative stress
Rats
Rats, Sprague-Dawley
Reproductive toxicity
Sperm Count
Spermatozoa - abnormalities
Spermatozoa - drug effects
Sprague-Dawley
Testis - drug effects
Testis - enzymology
Testis - pathology
Toxicity Tests, Chronic
总抗氧化能力
毒性效应
激素水平
生殖系统
还原型谷胱甘肽
阿特拉津
雄性大鼠
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Summary:Objective This study was designed to evaluate the toxic effects of Atrazine （ATZ） on the reproductive system of male rats. 〈br〉 Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels. Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group;a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups;decreased levels of acid phosphatase （ACP）, alkaline phosphatase （AKP）, lactic dehydrogenase （LDH）, and succinate dehydrogenase （SDH） with the increasing of ATZ concentration; a decreased level of total antioxidant capacity （TAC） in a dose-dependent manner, and a decreased reduced glutathione （GSH） level and an increased malondialdehyde （MDA） content in 154 mg/kg group;and decreased serum levels of testosterone （T） and inhibin-B （INH-B） and an increased serum level of follicle stimulating hormone （FSH） in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone （LH） in 154 mg/kg group. Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2014.050