Acrylamide Alters Cytoskeletal Protein Level in Rat Serum

To study biomarker of acrylamide （ACR） induced neuropathy, Wistar rats received 20 or 40 mg/kg of ACR by ip injection and the levels of light neurofilament （NF-L）, middle NF （NF-M）, heavy NF （NF-H）, β-actin, α-tubulin, and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western bl...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2013-11, Vol.26 (11), p.926-929
Main Authors: YU, Su Fang, SONG, Fu Ying, YI, Chao, YANG, Xi Wei, LI, Guo Zhen, ZHANG, Cui Li, ZHAO, Xiu Lan, XIE, Ke Qin
Format: Article
Language:English
Subjects:
Acrylamide - toxicity
Animals
Behavior, Animal - drug effects
Blotting, Western
Cytoskeletal Proteins - blood
Dose-Response Relationship, Drug
Electrophoresis, Polyacrylamide Gel
Gait Ataxia - blood
Gait Ataxia - chemically induced
Male
Motor Activity - drug effects
Neurotoxicity Syndromes - blood
Neurotoxicity Syndromes - etiology
NF-L
Rats
Rats, Wistar
SDS-PAGE
Western印迹
Wistar大鼠
丙烯酰胺
细胞骨架
蛋白水平
血清
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Summary:To study biomarker of acrylamide （ACR） induced neuropathy, Wistar rats received 20 or 40 mg/kg of ACR by ip injection and the levels of light neurofilament （NF-L）, middle NF （NF-M）, heavy NF （NF-H）, β-actin, α-tubulin, and β-tubulin proteins in serum were evaluated using both SDS-PAGE and Western blotting. Compared to controls, NF-L and NF-M decreased,
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2013.023