Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure

Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats（three exposure groups and a sham group）.Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2012-04, Vol.25 (2), p.182-188
Main Authors: ZHAO, Li, PENG, Rui Yun, WANG, Shui Ming, WANG, Li Feng, GAO, Ya Bing, DONG, Ji, LI, Xiang, SU, Zhen Tao
Format: Article
Language:English
Subjects:
Animals
Chromatography, High Pressure Liquid
Cognition
Hippocampus
Hippocampus - pathology
Hippocampus - physiopathology
Hippocampus - radiation effects
Learning
Learning and memory
Male
Memory
Microscopy, Electron, Transmission
Microwave
Microwaves
Morris水迷宫
Neurotransmitter
Rats
Rats, Wistar
Wistar大鼠
γ-氨基丁酸
微波辐射
海马结构
神经递质
认知功能障碍
高效液相色谱法
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Summary:Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats（three exposure groups and a sham group）.Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids（glutamate,aspartic acid,glycine,and gamma-aminobutyric acid） in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption.
ISSN:0895-3988
2214-0190
DOI:10.3967/0895-3988.2012.02.009