Association of Estrogen Receptor-α Gene Pvull Polymorphisms with the Effect of Calcium Supplementation on Skeletal Development in Chinese Pubertal Girls

Objective To investigate the association of estrogen receptor alpha （ER-c0 PvulI polymorphisms with the effect of calcium supplementation on bone development in Chinese pubertal girls, and to study the importance of calcium supplementation by maximizing the peak bone mass at their pubertal stage for...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2009-12, Vol.22 (6), p.480-487
Main Authors: Yang, Li-Chen, Zhang, Qian, Piao, Jian-Hua, Huang, Zheng-Wu, Hu, Xiao-Qi, Ma, Guan-Sheng
Format: Article
Language:English
Subjects:
Adolescent
Asian Continental Ancestry Group
Biomarkers
Bone Density - drug effects
Calcium - administration & dosage
Calcium - pharmacology
Dietary Supplements
Estrogen Receptor alpha - genetics
Female
Humans
Polymorphism, Genetic
Puberty - physiology
基因多态性
雌激素受体α
青春期
骨骼发育
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Summary:Objective To investigate the association of estrogen receptor alpha （ER-c0 PvulI polymorphisms with the effect of calcium supplementation on bone development in Chinese pubertal girls, and to study the importance of calcium supplementation by maximizing the peak bone mass at their pubertal stage for bone development and osteoporosis prevention and the role of estrogen in regulating bone mass. Methods Ninety-four pubertal girls were recruited in the study and divided into two groups and three sub-groups according to the ER-α PvulI polymorphisms. One year before and after calcium supplementation, bone mineral density （BMD） was measured by DEXA, while BGP, BAP, TRACP5b, and 25-OH-VitD3, as well as estrogen were detected by ELISA. Analysis of covariance was used to examine the effect of ER-ct polymorphisms on bone development. Results The absolute increase and percentage change of BGP were significantly higher in the supplemented group than in the control group （P〈0.05）. In the intervened group, The increase and percentage change of the total body and radio distal 1/3 BMD were higher in PP than in PP genotype （P〈0.05）, and the increase of BAP in Pp was also higher than PP in the same group （P〈0.05）. Conclusion PP genotype shows a better response to calcium supplementation than the other Pvull polymorphisms.
ISSN:0895-3988
2214-0190
DOI:10.1016/S0895-3988(10)60005-0