An efficient one pot synthesis of 1,4-dihydropyridines using alumina sulfuric acid (ASA) catalyst

An efficient synthetic method for 1,4-dihydropyridines has been developed using 3 or 4 component condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate in the presence of alumina sulfuric acid catalyst in minimum methanol at reflux temperature. This procedure offers seve...

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Bibliographic Details
Published in:Turkish journal of chemistry 2009-01, Vol.33 (6), p.769-774
Main Authors: ARSLAN, MUSTAFA, FAYDALI, CÜNEYT, ZENGİN, MUSTAFA, KÜÇÜKİSLAMOĞLU, MUSTAFA, DEMİRHAN, HÜLYA
Format: Article
Language:English
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Summary:An efficient synthetic method for 1,4-dihydropyridines has been developed using 3 or 4 component condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate in the presence of alumina sulfuric acid catalyst in minimum methanol at reflux temperature. This procedure offers several advantages including high yields, an environmentally friendly procedure, short reaction times, and a simple work-up procedure.
ISSN:1303-6130
1300-0527
1303-6130
DOI:10.3906/kim-0812-5