Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs

The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (GI) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activat...

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Bibliographic Details
Published in:11th International Symposium on Digestive Physiology of Pigs,Costa Daurada, Spain,2009-05-20 - 2009-05-22 Costa Daurada, Spain,2009-05-20 - 2009-05-22, 2010, Vol.133 (1), p.253-256
Main Authors: Prykhod'ko, O., Fed'kiv, O., Pierzynowski, S.G., Svendsen, J., Weström, B.R.
Format: Article
Language:English
Subjects:
acute phase proteins
Animal and Dairy Science
Biologi
Biological Sciences
blood chemistry
dosage
gastrointestinal system
hormone secretion
Husdjursvetenskap
immune response
Inflammation
insulin
Intestinal maturation
lactalbumin
leukocyte count
Natural Sciences
Naturvetenskap
oral administration
peptide hormones
Phytohaemagglutinin
phytohemagglutinin
Piglets
suckling
temporal variation
Veterinary Science
Veterinärmedicin
Weaning
weanlings
Zoologi
Zoology
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Summary:The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (GI) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the GI immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9–10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, α-lactalbumin ( n = 5–6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks. No significant differences in the blood parameters between PHA-treated pigs in comparison to their time-matched controls were found during the first week after treatment. At weaning significant changes in hormonal (insulin) and immune (WBC) parameters and CRP were observed, however, these effects were independent of earlier PHA treatment. In conclusion, PHA, given enterally as a single dose, did not affect the basal blood parameters analysed, during both the suckling and post-weaning periods in piglets.
ISSN:1871-1413
1878-0490
1878-0490
DOI:10.1016/j.livsci.2010.06.079