Investigation of sparse clinical sampling in light of baseline oscillations and between‐individual variability using pharmacokinetic/pharmacodynamic modelling

Cortisol exhibits a circadian rhythm in horses. It is a well‐known biomarker that is suppressed by dexamethasone. A sampling protocol of cortisol with one pre‐ and one post drug administration sample is used in dexamethasone suppression tests. However, diurnal fluctuation and inter‐individual variat...

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Bibliographic Details
Main Authors: Held, Felix, Ekstrand, C., Gabrielsson, J., Jirstrand, Mats
Format: Conference Proceeding
Language:English
Subjects:
Clinical Science
Klinisk vetenskap
Veterinary Science
Veterinärmedicin
Online Access:Get full text
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Summary:Cortisol exhibits a circadian rhythm in horses. It is a well‐known biomarker that is suppressed by dexamethasone. A sampling protocol of cortisol with one pre‐ and one post drug administration sample is used in dexamethasone suppression tests. However, diurnal fluctuation and inter‐individual variation may hamper the utility of test results. The aim of this study was to quantify the determinants of baseline fluctuation and between‐individual and between‐occasion variability for guidance of an improved test protocol.
ISSN:1365-2885
0140-7783
DOI:10.1111/jvp.12658