Associations between very low concentrations of low density lipoprotein cholesterol, high sensitivity C-reactive protein, and health outcomes in the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study

Recent findings have demonstrated the important contribution of inflammation to the risk of cardiovascular disease (CVD) in individuals with optimally managed low density lipoprotein cholesterol (LDL-C). We explored relationships between LDL-C, high sensitivity C-reactive protein (hs-CRP), and clini...

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Bibliographic Details
Published in:	European heart journal 2018-10, Vol.39 (40), p.3641-3653
Main Authors:	Penson, Peter E, Long, D Leann, Howard, George, Toth, Peter P, Muntner, Paul, Howard, Virginia J, Safford, Monica M, Jones, Steven R, Martin, Seth S, Mazidi, Mohsen, Catapano, Alberico L, Banach, Maciej
Format:	Article
Language:	eng
Subjects:	Aged C-Reactive Protein - analysis Cholesterol, LDL - blood Coronary Disease - blood Coronary Disease - epidemiology Coronary Disease - mortality Editor's Choice Fast Track Clinical Research Female Humans Longitudinal Studies Male Middle Aged Stroke - blood Stroke - epidemiology Stroke - mortality United States - epidemiology
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Summary:	Recent findings have demonstrated the important contribution of inflammation to the risk of cardiovascular disease (CVD) in individuals with optimally managed low density lipoprotein cholesterol (LDL-C). We explored relationships between LDL-C, high sensitivity C-reactive protein (hs-CRP), and clinical outcomes in a free-living US population. We used data from the REasons for Geographical And Racial Differences in Stroke (REGARDS), and selected individuals at 'high risk' for coronary events with a Framingham Coronary Risk Score of ≥10% or atherosclerotic cardiovascular disease (ASCVD) risk ≥7.5% in order to explore relationships between low LDL-C [
ISSN:	0195-668X 1522-9645 1522-9645