Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis

This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Coronary CTA can noninvasively assess coronary plaques quantitative...

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Published in:JACC. Cardiovascular imaging 2021-07, Vol.14 (7), p.1410-1421
Main Authors: Hwang, Doyeon, Kim, Haneol J., Lee, Seung-Pyo, Lim, Seonhee, Koo, Bon-Kwon, Kim, Yong-Jin, Kook, Woong, Andreini, Daniele, Al-Mallah, Mouaz H., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, Marques, Hugo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Leipsic, Jonathon A., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert L., Shin, Sanghoon, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Lee, Sang-Eun, Berman, Daniel S., Lin, Fay Y., Virmani, Renu, Samady, Habib, Stone, Peter H., Narula, Jagat, Bax, Jeroen J., Shaw, Leslee J., Min, James K., Chang, Hyuk-Jae
Format: Article
Language:English
Subjects:
coronary computed tomography angiography
coronary plaque
Medicin och hälsovetenskap
topological data analysis
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Summary:This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Coronary CTA can noninvasively assess coronary plaques quantitatively. Patients who underwent 2 coronary CTAs at a minimum of 24 months’ interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by topological data analysis (TDA) based on the whole-heart quantitative coronary plaque analysis on coronary CTA to identify distinct patient groups and their association with outcome. Three distinct patient groups were identified by TDA, and the patient similarity network by TDA showed a closed loop, demonstrating a continuous trend of coronary plaque progression. Group A had the least coronary plaque amount (median 12.4 mm3 [interquartile range (IQR): 0.0 to 39.6 mm3]) in the entire coronary tree. Group B had a moderate coronary plaque amount (31.7 mm3 [IQR: 0.0 to 127.4 mm3]) with relative enrichment of fibrofatty and necrotic core (32.6% [IQR: 16.7% to 46.2%] and 2.7% [IQR: 0.1% to 6.9%] of the total plaque, respectively) components. Group C had the largest coronary plaque amount (187.0 mm3 [IQR: 96.7 to 306.4 mm3]) and was enriched for dense calcium component (46.8% [IQR: 32.0% to 63.7%] of the total plaque). At follow-up, total plaque volume, fibrous, and dense calcium volumes increased in all groups, but the proportion of fibrofatty component decreased in groups B and C, whereas the necrotic core portion decreased in only group B (all p 
ISSN:1936-878X
1876-7591
1876-7591
DOI:10.1016/j.jcmg.2020.11.009