Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study

BACKGROUND—The global burden of atrial fibrillation (AF) is unknown. METHODS AND RESULTS—We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global Burden of Disease regions to estimate global/regional prevalence, incidence, and morbidity and mortality r...

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Published in:	Circulation (New York, N.Y.) N.Y.), 2014-02, Vol.129 (8), p.837-847
Main Authors:	Chugh, Sumeet S, Havmoeller, Rasmus, Narayanan, Kumar, Singh, David, Rienstra, Michiel, Benjamin, Emelia J, Gillum, Richard F, Kim, Young-Hoon, McAnulty, John H, Zheng, Zhi-Jie, Forouzanfar, Mohammad H, Naghavi, Mohsen, Mensah, George A, Ezzati, Majid, Murray, Christopher J.L
Format:	Article
Language:	eng
Subjects:	Adult Age Distribution Aged Atrial Fibrillation - epidemiology Atrial Fibrillation - mortality Biological and medical sciences Blood and lymphatic vessels Cardiac dysrhythmias Cardiology. Vascular system Cost of Illness Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Global Health - statistics & numerical data Heart Humans Incidence Male Medical sciences Medicin och hälsovetenskap Middle Aged Prevalence Quality-Adjusted Life Years Risk Factors Sex Distribution
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Summary:	BACKGROUND—The global burden of atrial fibrillation (AF) is unknown. METHODS AND RESULTS—We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global Burden of Disease regions to estimate global/regional prevalence, incidence, and morbidity and mortality related to AF (DisModMR software). Of 377 potential studies identified, 184 met prespecified eligibility criteria. The estimated number of individuals with AF globally in 2010 was 33.5 million (20.9 million men [95% uncertainty interval (UI), 19.5–22.2 million] and 12.6 million women [95% UI, 12.0–13.7 million]). Burden associated with AF, measured as disability-adjusted life-years, increased by 18.8% (95% UI, 15.8–19.3) in men and 18.9% (95% UI, 15.8–23.5) in women from 1990 to 2010. In 1990, the estimated age-adjusted prevalence rates of AF (per 100 000 population) were 569.5 in men (95% UI, 532.8–612.7) and 359.9 in women (95% UI, 334.7–392.6); the estimated age-adjusted incidence rates were 60.7 per 100 000 person-years in men (95% UI, 49.2–78.5) and 43.8 in women (95% UI, 35.9–55.0). In 2010, the prevalence rates increased to 596.2 (95% UI, 558.4–636.7) in men and 373.1 (95% UI, 347.9–402.2) in women; the incidence rates increased to 77.5 (95% UI, 65.2–95.4) in men and 59.5 (95% UI, 49.9–74.9) in women. Mortality associated with AF was higher in women and increased by 2-fold (95% UI, 2.0–2.2) and 1.9-fold (95% UI, 1.8–2.0) in men and women, respectively, from 1990 to 2010. There was evidence of significant regional heterogeneity in AF estimations and availability of population-based data. CONCLUSIONS—These findings provide evidence of progressive increases in overall burden, incidence, prevalence, and AF-associated mortality between 1990 and 2010, with significant public health implications. Systematic, regional surveillance of AF is required to better direct prevention and treatment strategies.
ISSN:	0009-7322 1524-4539 1524-4539