Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action

The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) α deficiency (IL-6RαL-KO mice). Th...

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Bibliographic Details
Published in:	Cell metabolism 2010-09, Vol.12 (3), p.237-249
Main Authors:	Wunderlich, F. Thomas, Ströhle, Peter, Könner, A. Christine, Gruber, Sabine, Tovar, Sulay, Brönneke, Hella S., Juntti-Berggren, Lisa, Li, Luo-Sheng, van Rooijen, Nico, Libert, Claude, Berggren, Per-Olof, Brüning, Jens C.
Format:	Article
Language:	eng
Subjects:	Adiposity Animals Energy Metabolism Glucose - metabolism Glycogen - biosynthesis Homeostasis Humans Inflammation - metabolism Insulin - metabolism Insulin Resistance - physiology Interleukin-10 - metabolism Interleukin-6 - metabolism Kupffer Cells - metabolism Liver - cytology Liver - metabolism Liver - pathology Medicin och hälsovetenskap Mice Mice, Knockout Receptors, Interleukin-6 - genetics Receptors, Interleukin-6 - metabolism Signal Transduction - physiology Tumor Necrosis Factor-alpha - metabolism
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Summary:	The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) α deficiency (IL-6RαL-KO mice). These animals showed no alterations in body weight and fat content but exhibited a reduction in insulin sensitivity and glucose tolerance. Impaired glucose metabolism originated from attenuated insulin-stimulated glucose transport in skeletal muscle and fat. Surprisingly, hepatic IL-6Rα-disruption caused an exaggerated inflammatory response during euglycemic hyperinsulinemic clamp analysis, as revealed by increased expression of IL-6, TNF-α, and IL-10, as well as enhanced activation of inflammatory signaling such as phosphorylation of IκBα. Neutralization of TNF-α or ablation of Kupffer cells restored glucose tolerance in IL-6RαL-KO mice. Thus, our results reveal an unexpected role for hepatic IL-6 signaling to limit hepatic inflammation and to protect from local and systemic insulin resistance. ► Hepatic IL-6 signaling improves local and systemic insulin action ► Hepatocyte IL-6 signaling limits inflammatory cytokine expression in liver ► Heptocyte IL-6 signaling controls TNF-α secretion from Kupffer cells ► Kupffer cell-derived cytokines can affect systemic insulin sensitivity
ISSN:	1550-4131 1932-7420 1932-7420