Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction

Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. Using data on patie...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2019-08, Vol.74 (5), p.601-612
Main Authors: Tromp, Jasper, Shen, Li, Jhund, Pardeep S., Anand, Inder S., Carson, Peter E., Desai, Akshay S., Granger, Christopher B., Komajda, Michel, McKelvie, Robert S., Pfeffer, Marc A., Solomon, Scott D., Køber, Lars, Swedberg, Karl, Zile, Michael R., Pitt, Bertram, Lam, Carolyn S.P., McMurray, John J.V.
Format: Article
Language:English
Subjects:
Adults
Age
Age Factors
Aged
Aged, 80 and over
Aldosterone
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Benzimidazoles - therapeutic use
Biphenyl Compounds - therapeutic use
Candesartan cilexetil
cardiac
Cardiac and Cardiovascular Systems
Cardiology
Cardiovascular System & Cardiology
clinical characteristics
Clinical outcomes
Clinical trials
comorbidities
Confidence intervals
Congestive heart failure
Death
dysfunction
Echocardiography
Ejection fraction
Epidermal growth factor receptors
Female
Fibrillation
Geriatrics
Global Health
Health risk assessment
Heart
Heart failure
Heart Failure - drug therapy
Heart Failure - epidemiology
Heart Failure - physiopathology
HFpEF
Humans
Hypertension
Irbesartan - therapeutic use
Kardiologi
Kidney diseases
Male
Men
Middle Aged
Mineralocorticoid Receptor Antagonists - therapeutic use
Morbidity
Morbidity - trends
Mortality
Older people
Patients
Peptides
predominance
Prognosis
Quality of life
Questionnaires
race
racial-differences
Reduction
spironolactone
Stroke Volume - physiology
structure
Studies
Survival Rate - trends
Systole
Tetrazoles - therapeutic use
Therapy
Ventricle
Ventricular Function, Left - physiology
young
young-adults
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Summary:Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. Using data on patients with left ventricular ejection fraction ≥45% from 3 large HFpEF trials (TOPCAT [Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function], I-PRESERVE [Irbesartan in Heart Failure With Preserved Systolic Function], and CHARM Preserved [Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity]), patients were categorized according to age: ≤55 years (n = 522), 56 to 64 years (n = 1,679), 65 to 74 years (n = 3,405), 75 to 84 years (n = 2,464), and ≥85 years (n = 398). This study compared clinical and echocardiographic characteristics, as well as mortality and hospitalization rates, mode of death, and quality of life across age categories. Younger patients (age ≤55 years) with HFpEF were more often obese, nonwhite men, whereas older patients with HFpEF were more often white women with a higher prevalence of atrial fibrillation, hypertension, and chronic kidney disease (eGFR 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2019.05.052