PET Imaging of Tau Deposition in the Aging Human Brain

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were dif...

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Published in:	Neuron (Cambridge, Mass.) Mass.), 2016-03, Vol.89 (5), p.971-982
Main Authors:	Schöll, Michael, Lockhart, Samuel N., Schonhaut, Daniel R., O’Neil, James P., Janabi, Mustafa, Ossenkoppele, Rik, Baker, Suzanne L., Vogel, Jacob W., Faria, Jamie, Schwimmer, Henry D., Rabinovici, Gil D., Jagust, William J.
Format:	Article
Language:	eng
Subjects:	60 APPLIED LIFE SCIENCES a-beta Adult age Age Factors Aged Aged, 80 and over Aging Alzheimer Disease - complications Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimers disease amyloid amyloid-beta Aniline Compounds - pharmacokinetics Apolipoproteins E - genetics Brain - diagnostic imaging Brain - metabolism categories cerebrospinal-fluid Cognition & reasoning Cognition Disorders - etiology episodic memory Ethylene Glycols - pharmacokinetics Female Humans Male memory mild cognitive impairment national institute neurofibrillary tangles Neurologi Neurology Neurosciences Neurosciences & Neurology Neurovetenskaper Older people Pathology PET Positron-Emission Tomography Psychiatric Status Rating Scales senile plaques tau tau Proteins - metabolism Thiazoles - pharmacokinetics Young Adult
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Summary:	Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition. [Display omitted] •AV-1451 PET imaging allows in vivo Braak tau staging based on tracer uptake•Age and β-amyloid are associated with different patterns of tau tracer retention•Medial temporal tau tracer retention relates to episodic memory decline in aging Schöll, Lockhart, et al. examined tau pathology in vivo using 18F-AV-1451 (tau) PET in healthy aging and found relationships with cognitive function. Confirming neuropathologically established patterns, they also detected different effects of age and β-amyloid on patterns of tau deposition.
ISSN:	0896-6273 1097-4199