Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection

Introduction Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. Methods Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive...

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Published in:Intensive care medicine 2011-02, Vol.37 (2), p.272-283
Main Authors: Martin-Loeches, I., Lisboa, T., Rhodes, A., Moreno, R. P., Silva, E., Sprung, C., Chiche, J. D., Barahona, D., Villabon, M., Balasini, C., Pearse, R. M., Matos, R., Rello, J.
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Language:eng
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Summary:Introduction Early use of corticosteroids in patients affected by pandemic (H1N1)v influenza A infection, although relatively common, remains controversial. Methods Prospective, observational, multicenter study from 23 June 2009 through 11 February 2010, reported in the European Society of Intensive Care Medicine (ESICM) H1N1 registry. Results Two hundred twenty patients admitted to an intensive care unit (ICU) with completed outcome data were analyzed. Invasive mechanical ventilation was used in 155 (70.5%). Sixty-seven (30.5%) of the patients died in ICU and 75 (34.1%) whilst in hospital. One hundred twenty-six (57.3%) patients received corticosteroid therapy on admission to ICU. Patients who received corticosteroids were significantly older and were more likely to have coexisting asthma, chronic obstructive pulmonary disease (COPD), and chronic steroid use. These patients receiving corticosteroids had increased likelihood of developing hospital-acquired pneumonia (HAP) [26.2% versus 13.8%, p  
ISSN:0342-4642
1432-1238
1432-1238