Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of

Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (17), p.7119-7124
Main Authors:	Schumann, Gunter, Coin, Lachlan J, Lourdusamy, Anbarasu, Charoen, Pimphen, Berger, Karen H, Stacey, David, Desrivières, Sylvane, Aliev, Fazil A, Khan, Anokhi A, Aulchenko, Yurii S, Bakalkin, Georgy, Bakker, Stephan J, Balkau, Beverley, Beulens, Joline W, Bilbao, Ainhoa, de Boer, Rudolf A, Beury, Delphine, Bots, Michiel L, Cauchi, Stéphane, Cavalcanti-Proença, Christine, Chambers, John C, Clarke, Toni-Kim, Dahmen, Norbert, de Geus, Eco J, Dick, Danielle, Ducci, Francesca, Easton, Alanna, Esk, Tõnu, Foroud, Tatiana, Freimer, Nelson B, Girault, Jean-Antoine, Grobbee, Diederick E, Guarrera, Simonetta, Gudbjartsson, Daniel F, Hartikainen, Anna-Liisa, Heath, Andrew C, Hesselbrock, Victor, Hottenga, Jouke-Jan, Kaprio, Jaakko, Khaw, Kay-Tee, Kuehnel, Brigitte, Laitinen, Jaana, Luan, Jian'an, Mangino, Massimo, Maroteaux, Matthieu, Matullo, Giuseppe, Mueller, Christian, Navis, Gerjan, Numans, Mattijs E, Núñez, Alejandro, Nyholt, Dale R, Onland-Moret, Charlotte N, Oostra, Ben A, O'Reilly, Paul F, Palkovits, Miklos, Penninx, Brenda W, Polidoro, Silvia, Pouta, Anneli, Prokopenko, Inga, Ricceri, Fulvio, Santos, Eugenio, Smit, Johannes H, Soranzo, Nicole, Song, Kijoung, Sovio, Ulla, Stumvoll, Michael, Surakk, Ida, Thorgeirsson, Thorgeir E, Thorsteinsdottir, Unnur, Troakes, Claire, Tyrfingsson, Thorarinn, Tönjes, Anke, Uiterwaal, Cuno S, Uitterlinden, Andre G, van der Harst, Pim, van der Schouw, Yvonne T, Staehlin, Oliver, Waeber, Gerard, Wareham, Nicholas J, Wichmann, Erich H, Witteman, Jacqueline C, Yuan, Xin, Zhai, Guangju, Zhao, Jing H, Zhang, Weihua, Martin, Nicholas G, Metspalu, Andres, Doering, Angela, Scott, James, Spector, Tim D, Loos, Ruth J, Boomsma, Dorret I, Peltonen, Leena, van Duijn, Cornelia M, Vineis, Paolo, Kooner, Jaspal S, Spanagel, Rainer, Heberlein, Ulrike A, Jarvelin, Marjo-Riitta, Elliott, Paul
Format:	Article
Language:	eng
Subjects:	Alcohol drinking Alcohol Drinking - genetics Alcohol Drinking - metabolism Alcohol use Alcohols Alleles ancestry Animals Autism Behavioral genetics Biological Sciences Body weight Brain cortex Cortex (prefrontal) Cytoskeletal Proteins Drinking behavior Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism epidemiologic Epidemiology Ethanol Female Gene expression Gene Expression Regulation - genetics genes genome-wide analysis Genome-Wide Association Study Genomes Genotype Genotype & phenotype Genotyping Human genetics Humans Male Medical genetics Medical research MEDICIN MEDICINE meta-analysis Mice Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Polymorphism, Single Nucleotide Proteins - genetics Proteins - metabolism Quantitative Trait, Heritable Replication Research universities Rodents Single-nucleotide polymorphism Transcription Factors transcriptional expression analysis Whites - genetics
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