Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

Yersinia pseudotuberculosis is an enteropathogenic bacteria that disrupts the intestinal barrier and invades its host through gut-associated lymphoid tissue and Peyer's patches (PP). We show that the Y. pseudotuberculosis effector YopJ induces intestinal barrier dysfunction by subverting signal...

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Bibliographic Details

Published in:	Cell host & microbe 2012-04, Vol.11 (4), p.337-351
Main Authors:	Meinzer, Ulrich, Barreau, Frederick, Esmiol-Welterlin, Sophie, Jung, Camille, Villard, Claude, Léger, Thibaut, Ben-Mkaddem, Sanah, Berrebi, Dominique, Dussaillant, Monique, Alnabhani, Ziad, Roy, Maryline, Bonacorsi, Stéphane, Wolf-Watz, Hans, Perroy, Julie, Ollendorff, Vincent, Hugot, Jean-Pierre
Format:	Article
Language:	eng
Subjects:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry, Molecular Biology Caspase 1 - genetics Caspase 1 - metabolism Cell Line Female Humans Intestines - enzymology Intestines - metabolism Intestines - microbiology Life Sciences Male MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred C57BL Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism Signal Transduction Yersinia pseudotuberculosis - genetics Yersinia pseudotuberculosis - metabolism Yersinia pseudotuberculosis Infections - enzymology Yersinia pseudotuberculosis Infections - genetics Yersinia pseudotuberculosis Infections - metabolism Yersinia pseudotuberculosis Infections - microbiology
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