Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets

Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from plate...

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Bibliographic Details

Published in:	Cancer cell 2017-08, Vol.32 (2), p.238-252.e9
Main Authors:	Best, Myron G., Sol, Nik, In ‘t Veld, Sjors G.J.G., Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna-Larissa N., Fejes, Aniko V., Tjon Kon Fat, Lee-Ann, Huis In ‘t Veld, Anna E., Leurs, Cyra, Le Large, Tessa Y., Meijer, Laura L., Kooi, Irsan E., Rustenburg, François, Schellen, Pepijn, Verschueren, Heleen, Post, Edward, Wedekind, Laurine E., Bracht, Jillian, Esenkbrink, Michelle, Wils, Leon, Favaro, Francesca, Schoonhoven, Jilian D., Tannous, Jihane, Meijers-Heijboer, Hanne, Kazemier, Geert, Giovannetti, Elisa, Reijneveld, Jaap C., Idema, Sander, Killestein, Joep, Heger, Michal, de Jager, Saskia C., Urbanus, Rolf T., Hoefer, Imo E., Pasterkamp, Gerard, Mannhalter, Christine, Gomez-Arroyo, Jose, Bogaard, Harm-Jan, Noske, David P., Vandertop, W. Peter, van den Broek, Daan, Ylstra, Bauke, Nilsson, R. Jonas A., Wesseling, Pieter, Karachaliou, Niki, Rosell, Rafael, Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B., Tannous, Bakhos A., de Langen, Adrianus J., Smit, Egbert F., van den Heuvel, Michel M., Wurdinger, Thomas
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Algorithms Artificial Intelligence Biomarkers, Tumor blood platelets Blood Platelets - physiology cancer diagnostics Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Cohort Studies Diagnosis, Computer-Assisted - methods Female Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Inflammation - blood Inflammation - diagnosis Inflammation - genetics liquid biopsies Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Middle Aged NSCLC particle-swarm optimization RNA self-learning algorithms splicing Support Vector Machine swarm intelligence tumor-educated platelets
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