B vitamins improve health in patients with coeliac disease living on a gluten-free diet

Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. Methods In a double blind placebo controlled...

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Bibliographic Details
Published in:	Alimentary pharmacology & therapeutics 2009, Vol.29 (8), p.811
Main Authors:	Hallert, Claes, Svensson, M., Tholstrup, J., Hultberg, B.
Format:	Article
Language:	eng
Subjects:	Coeliac disease Dermatologi och venerologi, klinisk genetik, invärtesmedicin Dermatology and venerology,clinical genetics, internal medicine Gastroenterologi Gastroenterology Internal medicine Invärtesmedicin MEDICIN MEDICINE
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Summary:	Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status. Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 μmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 μmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being. Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.
ISSN:	1365-2036 0269-2813 1365-2036