Phenotypic characteristics and SHV gene distribution of extended spectrum β-lactamase (ESBL)-producing Acinetobacter baumannii from Dr. M. Djamil Hospital Padang

Antibiotic resistance is becoming a serious problem in global health. One of the concerns was Extended-spectrum beta-lactamases (ESBLs) producing Acinetobacter baumannii which is usually encoded by the SHV gene so that it can be resistant to penicillins and third-generation cephalosporins. Our study...

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Bibliographic Details
Main Authors: Linosefa, Linosefa, Fortuna, Fory
Format: Conference Proceeding
Language:English
Subjects:
Antibiotics
Cephalosporins
Health care facilities
Public health
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Summary:Antibiotic resistance is becoming a serious problem in global health. One of the concerns was Extended-spectrum beta-lactamases (ESBLs) producing Acinetobacter baumannii which is usually encoded by the SHV gene so that it can be resistant to penicillins and third-generation cephalosporins. Our study was conducted to characterize ESBL-producing Acinetobacter baumannii phenotypically and configure SHV gene distribution in Padang, Indonesia. A total of 159 isolates were enrolled in this study. The highest sensitivity was to amikacin (85%) and 67,3 % were ESBL producers. Only 27% of ESBL-producing Acinetobacter baumannii had the SHV gene. ESBL-producing Acinetobacter baumannii is resistant to commonly administered antibiotics. Continuous antimicrobial resistance surveillance and quick detection of ESBL isolates are needed especially in healthcare facilities for the selection of appropriate treatments and to enhance infection control policies.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0127769