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Physicochemical characteristic of 99mTc-DTPA-deoxy-D-glucose radiopharmaceutical
Cancer is a genetic disease that causes by mutations in DNA from a normal cell to a cancer cell. As a result, the cancer cell grows quickly and spread to other parts of the body; this condition became the leading cause of death. One of the detection methods currently used to detect tumors and metast...
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Main Authors: | , , , , |
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Format: | Conference Proceeding |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Cancer is a genetic disease that causes by mutations in DNA from a normal cell to a cancer cell. As a result, the cancer cell grows quickly and spread to other parts of the body; this condition became the leading cause of death. One of the detection methods currently used to detect tumors and metastatic tissues is conducted with radiopharmaceutical of [18F] fluoro-2-deoxy-2-D-glucose (18F-FDG). This method is quite accurate but is relatively expensive because it needs PET / CT camera that is still limited in Indonesia. With these limitations, in previous studies was developed 99mTc-DTPA-deoxy-D-glucose (99mTc-DTPA-DG) radiopharmaceutical that application using a gamma camera. As new radiopharmaceuticals, the physical and chemical characteristics of these compounds must be known. In this study, physicochemical characterization tests determined radiochemical purity, electric charge, lipophilicity (log P), and plasma protein binding. The study determines that 99mTc-DTPA-DG radiopharmaceuticals have high radiochemical purity (95.28 ± 0.87 %), neutral electric charge, the lipophilic value (log P) -1.24 and the plasma protein binding was 72.09 ± 1.65 %. The 99mTc-DTPA-DG radiopharmaceuticals liquid kit that storage up to 60 days in -20oC or additional volumes of technetium-99m up to 3 mL still gives radiochemical purity above 95%. This study obtained physicochemical characteristics that can be used as reference in a subsequent in-vivo study of 99mTc-DTPA-DG radiopharmaceutical. A comprehensive information on the bioactivity of this compound for diagnostic cancer can be obtained from an in-vivo study. |
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ISSN: | 0094-243X 1551-7616 |
DOI: | 10.1063/5.0110202 |