Blood plasma cytokines releasing after implantation of self-expanding nitinol stents modified with silicon in experimental animals

Intravascular artery prosthetics in atherosclerotic lesion is one of the most frequently performed procedures in cardiovascular surgery to date. However, after the stent implantation a localized inflammatory reaction develops in the vascular wall that can lead to intimal hyperplasia and the developm...

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Main Authors: Chepeleva, E., Kozyr, K., Zubarev, D., Kudriashov, A., Kretov, E., Vasilieva, M., Kashin, O., Lotkov, A., Krukovskiy, K., Slabodchikov, V., Sergeevichev, D.
Format: Conference Proceeding
Language:English
Subjects:
Atherosclerosis
Biocompatibility
Blood cells
Blood plasma
Cytokines
Implantation
Intermetallic compounds
Nickel titanides
Prostheses
Shape memory alloys
Silicon
Stents
Submerging
Surface treatment
Surgical implants
Swine
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Summary:Intravascular artery prosthetics in atherosclerotic lesion is one of the most frequently performed procedures in cardiovascular surgery to date. However, after the stent implantation a localized inflammatory reaction develops in the vascular wall that can lead to intimal hyperplasia and the development of restenosis. Various methods of stent surface treatment are used to increase biocompatibility and reduce the allergic effect of the stent material on the body in order to increase the likelihood of postoperative complications. In this research we investigated the effect of modified stents made of nitinol and treated with plasma-immersion ionic surface processing with silicon on the specific products (mediators of inflammation) release activation from peripheral blood cells in mini-pigs.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5083291