Sodium alginate/gelatin with silica nanoparticles a novel hydrogel for 3D printing

Sodium alginate/gelatin hydrogels are promising materials for 3D bio-printing due to its good biocompatibility and biodegradability. Gelatin is used for thermal crosslinking and its cell adhesion properties. Hence patient specific sodium alginate/gelatin hydrogel scaffolds can be bio-fabricated in a...

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Bibliographic Details
Main Authors: Soni, Raghav, Roopavath, Uday Kiran, Mahanta, Urbashi, Deshpande, A. S., Rath, S. N.
Format: Conference Proceeding
Language:English
Subjects:
Biocompatibility
Biodegradability
Bioengineering
Cell adhesion
Cosmetics industry
Crosslinking
Degradation
Gelatin
Hydrogels
Invertebrates
Nanoparticles
Silica gel
Silicon dioxide
Sodium
Sodium alginate
Structural stability
Swelling
Three dimensional printing
Tissue engineering
Viscosity
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Summary:Sodium alginate/gelatin hydrogels are promising materials for 3D bio-printing due to its good biocompatibility and biodegradability. Gelatin is used for thermal crosslinking and its cell adhesion properties. Hence patient specific sodium alginate/gelatin hydrogel scaffolds can be bio-fabricated in a temperature range of 4-14 oC. In this study we made an attempt to introduce silica (SiO2) nanoparticles in the polymer network of sodium alginate (2.5%)/gelatin (8%) hydrogel at different concentrations (w/v) as 0%, 1.25%, 2.5%, 5%, and 7.5%. The effect of silica nanoparticles on viscosity, swelling behavior, and degradation rate are analyzed. Hydrogels with 5% silica nanoparticles show significantly less swelling and degradation when compared to other concentrations. The viscosity of the hydrogels gradually increases up to 5% addition of silica nanoparticles enhancing the stability of 3D printed structures.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5038681