Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients

Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders. To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluat...

Full description

Saved in:
Bibliographic Details
Published in:Anais brasileiros de dermatología 2023-03, Vol.98 (2), p.181-188
Main Authors: Farag, Azza Gaber Antar, Shoeib, Mohamed Abd AlMoneam, labeeb, Azza Zagloul, Sleem, Asmaa Shaaban, Khallaf, Hagar Mahmoud AbdElkader, Khalifa, Amany Salah, Elshaib, Mustafa Elsayed, Elnaidany, Nada Farag, Hanout, Hayam Mohamed Aboelnasr
Format: Article
Language:eng ; por
Subjects:
beta-Defensins - genetics
Case-Control Studies
DERMATOLOGY
Egypt
Genes
Genetic Predisposition to Disease
Genotype
Humans
Original
Polymorphism, genetic
Polymorphism, Single Nucleotide - genetics
Vitiligo
Vitiligo - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders. To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluation of HBD-1 serum levels and its single nucleotide polymorphism (SNP) in patients having NSV, in addition, to correlating the results with the extent of vitiligo in those patients. A current case-control study included 50 patients having NSV and 50 controls. The authors used Vitiligo Area Scoring Index (VASI) score to assess vitiligo severity and laboratory investigations to assess serum HBD-1 level using ELISA and defensin-beta1 (DEFB1) SNP using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There were significantly lower HBD-1 serum levels in NSV cases than in controls (p 
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1016/j.abd.2022.04.002