Comparative central effects of the aqueous leaf extract of two populations of Passiflora edulis

Passiflora edulis Sims, Passifloraceae, has been used in Brazilian traditional folk medicine to the treatment of anxiety and insomnia. P. edulis is commonly known for its economic interests in Brazil. This species exhibits significant variability in the fruit rind color, then two subpopulations has...

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Published in:Revista brasileira de farmacognosia 2015-09, Vol.25 (5), p.499-505
Main Authors: Ayres, Adriana S.F.S.J., de Araújo, Luana L.S., Soares, Thaciane C., Costa, Geison M., Reginatto, Flávio H., Ramos, Freddy A., Castellanos, Leonardo, Schenkel, Eloir P., Soares-Rachetti, Vanessa P., Zucolotto, Silvana M., Gavioli, Elaine C.
Format: Article
Language:eng ; por
Subjects:
Animal models
Antidepressant
Anxiolytic
Original Article
Passiflora edulis edulis
Passiflora edulis flavicarpa
PHARMACOLOGY & PHARMACY
Pharmacy
Sedation
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Summary:Passiflora edulis Sims, Passifloraceae, has been used in Brazilian traditional folk medicine to the treatment of anxiety and insomnia. P. edulis is commonly known for its economic interests in Brazil. This species exhibits significant variability in the fruit rind color, then two subpopulations has been described (P. edulis fo. flavicarpa O. Deg. (PEF); P. edulis fo. edulis (PEE)). This study compared phytochemical profile and biological actions of aqueous leaf extract of PEE and PEF. HPLC analysis showed marked distinct chromatograms to the P. edulis varieties. However, in both extracts the major compounds observed were flavonoids C-glycosides. Behavioral studies showed that PEE (300mg/kg, p.o.) and PEF (100 and 300mg/kg, p.o.) reduced anxiety in the elevated plus maze test. PEE (300 and 1000mg/kg, p.o.) and PEF (1000mg/kg, p.o.) also induced antidepressant-like actions in the forced swimming test. PEE 1000mg/kg significantly reduced distance moved, thus suggesting sedation. No alterations in sleeping time were observed with PEE and PEF extracts. In conclusion, despite the similarities between the biological actions observed for both P. edulis varieties, quite different phytochemical profile was herein reported. These data suggest that the anxiolytic and antidepressant actions are not due to a specific phytochemical component.
ISSN:0102-695X
1981-528X
1981-528X
DOI:10.1016/j.bjp.2015.06.007