Antiacetylcholinesterase and antioxidant activity of essential oils from six medicinal plants from Burkina Faso

In this investigation, we evaluated essential oils from six medicinal plants from Burkina Faso for their antiacetylcholinesterase and antioxidant abilities. The chemotype of most active were also determined. The best antiacetylcholinesterase activities were recorded for the essential oils of Eucalyp...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia 2011-02, Vol.21 (1), p.63-69
Main Authors: Kiendrebeogo, Martin, Coulibaly, Ahmed Y., Nebie, Roger C. H., Zeba, Boukaré, Lamien, Charles E., Lamien-Meda, Aline, Nacoulma, Odile G.
Format: Article
Language:eng ; por
Subjects:
PHARMACOLOGY & PHARMACY
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Summary:In this investigation, we evaluated essential oils from six medicinal plants from Burkina Faso for their antiacetylcholinesterase and antioxidant abilities. The chemotype of most active were also determined. The best antiacetylcholinesterase activities were recorded for the essential oils of Eucalyptus camaldulensis (IC50 18.98 µ g/mL) and Ocimum canum (IC50 36.16 µ g/mL). Their chemotype have been related to the 1,8-cineole one. Both essential oils demonstrated a linear mixed non competitive inhibition. The essential oil of Ocimum basilicum which belong to the linalool-eugenol chemotype exhibited the best radical scavenging activity (IC50 3.82 µ g/mL) and reducing power (531.75 mg AAE/g). In comparison with gallic and ascorbic acids, O. basilicum essential oil evidenced interesting antioxidant activities. The antiacetylcholinesterase and antioxidant activities of essential oils were discussed in regard with their chemical composition.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2011005000008